Magnesium fluoromalonates
US5101068A · kind A · utility
6Cited by
1References
7Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 16, 1990 |
| Grant date | Mar 31, 1992 |
| Priority date | — |
| Expiry date | Feb 16, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/273
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The preparation of magnesium benzyl fluoromalonate and other equivalent materials, the synthetic equivalents of the --CH.sub.2 F moiety, is described. Reaction between these reagents and the in situ-formed imidazolides of various carboxylic acids gives beta-keto-alpha-fluoroesters, which upon hydrogenation and spontaneous decarboxylation yields fluoromethyl ketones in excellent yields. The overall transformation from RCOOH to RCOCH.sub.2 F is thus illustrated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.