Method for preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiaze pine-4-one and chlorinated derivatives thereof
US5102998A · kind A · utility
3Cited by
5References
6Claims
0Family size
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Key dates
| Filing date | Oct 24, 1989 |
| Grant date | Apr 7, 1992 |
| Priority date | — |
| Expiry date | Oct 24, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D281/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2-Aminothiophenol is reacted with methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate, and the intermediate methyl (2S,3S)-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)propionate is cyclized in the presence of methanesulfonic acid, in the same vessel and without isolating said intermediate product, using e.g. chlorobenzene as a solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.