Process for preparing 4-demethoxydaunomycinone
US5103029A · kind A · utility
4Cited by
7References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 6, 1989 |
| Grant date | Apr 7, 1992 |
| Priority date | — |
| Expiry date | Apr 6, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyldaunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound, in an appropriate reducing environment, with a catalytic amount of a transition metal complex, preferably palladium or nickel with 1,3 diphenylphosphinopropane or 1,1'-bis (diphenylphosphino) ferrocene, and eliminating the 13-dioxolanyl group by treatment with trifluoroacetic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.