Process for improving the biostability of tissue implant devices and bioprosthetic implants so produced
US5104405A · kind A · utility
66Cited by
1References
22Claims
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Inventor
Key dates
| Filing date | Feb 21, 1991 |
| Grant date | Apr 14, 1992 |
| Priority date | — |
| Expiry date | Feb 21, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/918
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Processes are disclosed for improving the biostability of tissue implant devices. The processes comprise methods for treating harvested tissue with calcification inhibitor, tissue crosslinking reagent, and reagents capable of forming additional tissue reaction sites providing bioprosthetic devices having enhanced amounts of tissue bound calcification inhibitor. After long-term implantation, the treated tissue remains calcification free and exhibits a high degree of physical stability which minimizes the risk of mechanical failure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.