Antimycotically active substituted 2-aminothiazoles

US5104879A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Joachim Ippen · Leverkusen, DE
• Bernd Baasner · Bensberg, DE
• Klaus Schaller · Wuppertal, DE
• Miklos von Bittera · Leverkusen, DE

Key dates

• Filing date: Oct 11, 1990
• Grant date: Apr 14, 1992
• Expiry date: Oct 11, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antimicotically active 2-aminothiazoles have been found having the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl and PA0 R.sup.2 represents optionally substituted cyclohexyl or phenyl which is substituted by halogen, alkyl, halogenoalkyl, halogenoalkoxy, dioxyhalogenoalkyl or halogenoalkylthio, and their physiologically tolerable acid addition salts, PA0 with the exception of the compounds 4-(4-chlorophenyl)-2-[2-(1,4,5,6-tetrahydropyrimidinyl)-amino]thiazole and 4-(2,4-dichlorophenyl)-2-[2-(1,4,5,6-tetrahydropyrimidinyl)-amino]-thiazol e and 4-(4-chloro-2-methylphenyl)-2-[2-(1,4,5,6-tetrahydropyrimidinyl)-amino]-th iazole and with the exception of the physiologically tolerable acid addition salts of these compounds have been found.