Ribosome-inactivating glycoproteins, modified by oxidation of their osidic units and formation of a Schiff's base and in-vivo prolonged action immunotoxins containing such a glycoprotein
US5104976A · kind A · utility
2Cited by
4References
10Claims
0Family size
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Key dates
| Filing date | Sep 8, 1989 |
| Grant date | Apr 14, 1992 |
| Priority date | — |
| Expiry date | Sep 8, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/863
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Glycoprotein which inactivates ribosomes (GPIR) the ribosome-inhibiting activity of the native GPIR and having a prolonged-action in vivo which is obtained by oxidation of its osidic units by the action of periodate ions, and simultaneous blocking of the oxidation product by formation of a Schiff's base with a suitable primary amine. Said modified glycoprotein may be coupled to an antibody or a fragment thereof in order to form an immunotoxin.
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