Process for the preparation of 3-aryl-3-aminoalkyl-2,6-dioxohexahydropyridines
US5104990A · kind A · utility
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2Claims
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Key dates
| Filing date | Feb 27, 1990 |
| Grant date | Apr 14, 1992 |
| Priority date | — |
| Expiry date | Feb 27, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/88
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a process for the preparation of 3-aryl-3-aminoalkyl-2,6-dioxohexahydropridines and particularly the compounds 3-[3-(dimethylamino)propyl]-3-(3-methoxyphenyl)-4, 4-dimethyl-2,6-piperidinedione, monohydrochloride, which is useful as an antidepressant. the process of the present invention comprises the condensation of a sterically hindered nitrile with a sterically hindered .alpha., .beta.-unsaturated diester to produce a nitrile diester. These compounds can then undergo acid catalyzed cyclization and decarboalkoxylation in a one step process to provide the desired 3-aryl-3-aminoalkyl-2,6-dioxohexahydropyridine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.