Preparation of inactivated viral vaccines
US5106619A · kind A · utility
47Cited by
1References
12Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 10, 1990 |
| Grant date | Apr 21, 1992 |
| Priority date | — |
| Expiry date | Jan 10, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/20234
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Vaccines employing inactivated viruses having improved retention of antigenic characteristics are prepared by psoralen-inactivation of the live virus in a non-oxidizing atmosphere. By excluding oxygen and other oxidizing species from the inactivation medium, degradation of the antigen characteristics resulting from irradiation with ultraviolet light is largely prevented. The resulting inactivated viruses are employed in vaccine preparations for the inoculation of susceptible hosts to inhibit viral infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.