Method for visualizing the base sequence of nucleic acid polymers
US5106729A · kind A · utility
32Cited by
1References
20Claims
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Key dates
| Filing date | Jul 24, 1989 |
| Grant date | Apr 21, 1992 |
| Priority date | — |
| Expiry date | Jul 24, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/853
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for determining and visualizing the base sequence of nucleic acid olymers, especially DNA and RNA, with a scanning probe microscope having a tip, the method including replacing the oxygen in the nucleic acid polymer with sulfur, complexing the sulfur with a metal such as mercury, and passing the tip over the complexed polymer in a scanning path to measure the potential and record the difference in electrical conductivity at preselected increments along the scanning path.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.