Anticonvulsive substituted-9-benzyl-9H-purines
US5110818A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 19, 1990 |
| Grant date | May 5, 1992 |
| Priority date | — |
| Expiry date | Dec 19, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel 9H-purine derivatives, especially to the novel substituted 9-benzyl-9H-purines of the general formula ##STR1## in which Ph is a phenyl radical substituted by halogen, R.sub.1 is hydrogen or a free amino group or an amino group that is substituted aliphatically, cycloaliphatically, cycloaliphatically-aliphatically and/or by acyl, and R.sub.2 is halogen, lower alkoxy, lower alkyl, a free amino group, or an amino group that is substituted aliphatically, cycloaliphatically, cycloaliphatically-aliphatically and/or by acyl, with the proviso that R.sub.2 is other than halogen when Ph is 2-fluorophenyl or 2,5- or 2,6-difluorophenyl and R.sub.1 is a radical of the formula --N(R.sub.11)(R.sub.12) (Ia) in which either R.sub.11 is hydrogen, methyl or ethyl and R.sub.12 is hydrogen, methyl, hydroxymethyl, ethyl, n-propyl, isopropyl, cyclopropyl, cyclopenthyl or cyclopropylmethyl, or R.sub.11 is hydrogen and R.sub.12 is methoxymethyl, and with the further proviso that R.sub.2 is other than chlorine when Ph is 3-chlorophenyl, 4-chlorophenyl or 3,4-dichlorophenyl and R.sub.1 is N,N-dimethylamino, and to the novel compounds of formula I in which Ph is 2-fluorophenyl o…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.