Purification of Il-2-containing hybrid compounds
US5110912A · kind A · utility
1Cited by
4References
9Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 2, 1990 |
| Grant date | May 5, 1992 |
| Priority date | — |
| Expiry date | Mar 2, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/75
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for purifying from a mixture of hybrid compound which contains a portion of IL-2, which portion includes at least a region of the IL-2R binding domain of IL-2, which region is effective to cause the hybrid compound to bind to cells containing an IL-2R. The method includes passing the mixture containing the hybrid compound over a column having attached thereto molecules consisting of or containing a complex sugar moiety with affinity for the hybrid compound, and eluting the hybrid compound with a suitable eluant. The invention also features related complexes of the hybrid compound and assays for the hybrid compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.