New organoboron reagents for the preparation unsubstituted propargylic alcohols
US5110966A · kind A · utility
0Cited by
2References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 20, 1991 |
| Grant date | May 5, 1992 |
| Priority date | — |
| Expiry date | Jun 20, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/0803
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The novel organoboron reagent of the present invention is useful in the preparation of unsubstituted propargylic alcohols. This compound reacts with aldehydes and ketones cleanly to afford propargylic alcohols in excellent yields. Unsubstituted propargylic alcohols are important synthetic intermediates in the synthesis of a number of natural products. In addition, the novel organoboron reagent of the present invention also demonstrates diastereomeric selectivity when reacted with enatiomerically pure aldehydes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.