Kit for preparing a technetium-99m myocardial imaging agent
US5112594A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 4, 1991 |
| Grant date | May 12, 1992 |
| Priority date | — |
| Expiry date | Apr 4, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A myocardial imaging agent for use in humans comprising a Tc(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atotms and two furanone rings and in the axial positions by phosphines containing dioxanyl or ether moieties. The agent exhibits improved biodistribution, improved labeling and extremely rapid blood clearance following administration to a human. The agent has high myocardial uptake accompanied with exceptionally rapid hepatobilary clearance and extensive renal clearance to give sufficiently high heart/liver and heart/lung ratio that provide nearly ideal myocardial images in humans. A kit for producing the myocardial imaging agent is provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.