Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
US5112596A · kind A · utility
132Cited by
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16Claims
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Key dates
| Filing date | Apr 23, 1990 |
| Grant date | May 12, 1992 |
| Priority date | — |
| Expiry date | Apr 23, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The permeability of the blood-brain barrier to endogenous or exogenous neuropharmaceutical or diagnostic agents in an individual's blood stream is increased by administering a bradykinin agonist of blood-brain barrier permeability, such as N-acetyl [Phe.sup.8 (CH.sub.2 -NH)Arg.sup.9 ] bradykinin, to the individual. The bradykinin agonist of blood-brain barrier permeability is co-administered with the agent of interest into a blood vessel such as a vein. This co-administration allows the agent of interest to pass the blood-brain barrier into the brain compartment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.