Soluble hirudin conjugates
US5112615A · kind A · utility
22Cited by
14References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 4, 1990 |
| Grant date | May 12, 1992 |
| Priority date | — |
| Expiry date | Oct 4, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/813
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a soluble, biocompatible, pharmacological agent for inhibiting thrombin generation and thrombus formation, and methods for producing the same. The pharmacological agent or conjugate includes a soluble, biocompatible carrier and a thrombogenesis inhibitor immobilized thereto via the carrier which binds the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or active fragment thereof. The thrombogenesis inhibitor may be bound to the carrier via a bifunctional cross-linking reagent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.