Vaccines for the malaria circumsporozoite protein
US5112749A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 2, 1987 |
| Grant date | May 12, 1992 |
| Priority date | — |
| Expiry date | Oct 2, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/879
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to attenuated strains of enteroinvasive bacteria that express a peptide or protein related to an epitope of the malaria parasites of the genus Plasmodium. The bacterial strains of the invention which can multiply in a host without causing significant disease or disorder, and which express a Plasmodium-related peptide that induces a protective immune response against malaria, can be used in live vaccine formulations for malaria. In specific embodiments, a Plasmodium-related peptide can be expressed as a fusion protein, for example, with a bacterial enterotoxin. The invention also relates to methods for expression of malaria antigens or fragments thereof within attenuated enteroinvasive bacteria. In particular embodiments, the invention is directed to the expression by attenuated Salmonella spp. of epitopes of Plasmodium circumsporozoite proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.