Benzofuran compounds as class III antiarrhythmic agents

US5112824A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• John J. Baldwin · Gwynedd Valley, US
• Harold G. Selnick · Ambler, US
• Gerald S. Ponticello · Lansdale, US
• David C. Remy · North Wales, US
• David A. Claremon · Audubon, US
• Jason Matthew Elliott · Blue Bell, US

Key dates

• Filing date: Jul 15, 1991
• Grant date: May 12, 1992
• Expiry date: Jul 15, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of structural formula: ##STR1## wherein R' is hydrogen or an aromatic ring system, and Q is a substituted nitrogen or a nitrogen containing heterocycle, X and Y are bridging groups and p is 0 or 1, and E is --S-- or --O--, are Class III antiarrhythmic agents.