PLA.sub.2 inhibitors as antiinflammatories
US5112864A · kind A · utility
7Cited by
5References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 30, 1991 |
| Grant date | May 12, 1992 |
| Priority date | — |
| Expiry date | May 30, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to novel compounds for treating inflammatory conditions by inhibition of phospholipase A.sub.2 activity of the formula ##STR1## wherein X is oxygen, sulfur or --CH.dbd.CH--; wherein R.sup.1 is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation; PA1 wherein R.sup.2 is phenoxy, alkoxy, methyl, trifluoromethyl or phenyl; PA1 wherein n is an integer from 1 to 20; compositions comprised of the novel compounds; and methods of treating inflammatory conditions with these compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.