Synthesis of chroman derivatives

US5112972A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rolf Gericke · Seeheim-Jugenheim, DE
• Manfred Baumgarth
• Ingeborg Lues · Darmstadt, DE
• Rolf Bergmann
• De Peyer · Bern, CH

Key dates

• Filing date: May 31, 1990
• Grant date: May 12, 1992
• Expiry date: May 31, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new chroman derivatives of the formula I ##STR1## in which R.sup.1 is A, PA0 R.sup.2 and R.sup.8 are each H or A, PA0 R.sup.1 and R.sup.2 together are also alkylene with 3-6 C atoms, PA0 R.sup.3 is OH, OA or OAc, PA0 R.sup.4 is H, PA0 R.sup.3 and R.sup.4 together are also a bond, PA0 R.sup.5 is Ar or C.sub.n H.sub.2n -R.sup.9, PA0 R.sup.9 is alkenyl or alkynyl with 2-4 C atoms in each case, OH, OA, CHO, CO-A, CS-A, COOH, COOA, COO-alkyl-Ar, CS-OA, NO.sub.2, NH.sub.2, NHA, NA.sub.2, CN, F, Cl, Br, I, CF.sub.3, SA, SO-A, SO.sub.2 -A or Ar, PA0 Ar is a phenyl group which is unsubstituted or substituted once or twice by R.sup.10, R.sup.6, R.sup.7 and R.sup.10 are each H, A, HO, AO, CHO, ACO, CF.sub.3 CO, ACS, HOOC, AOOC, AO-CS, ACOO, A-CS-O, hydroxy-alkyl, mercapto-alkyl, NO.sub.2, NH.sub.2, NHA, NA.sub.2, CN, F, Cl, Br, I, CF.sub.3, AS, ASO, ASO.sub.2, AO-SO, AO-SO.sub.2, AcNH, AO-CO-NH, H.sub.2 NSO, HANSO, A.sub.2 NSO, H.sub.2 NSO.sub.2, HANSO.sub.2, A.sub.2 NSO.sub.2, H.sub.2 NCO, HANCO, A.sub.2 NCO, H.sub.2 NCS, HANCS, A.sub.2 NCS, ASONH, ASO.sub.2 NH, AOSONH, AOSO.sub.2 NH, ACO-alkyl, nitro-alkyl, cyano-alkyl, A-C(.dbd.NOH), A-C(.dbd.NNH.sub.2), H.sub.2 PO…