Analog of peptidase substrates
US5114927A · kind A · utility
8Cited by
1References
2Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 5, 1991 |
| Grant date | May 19, 1992 |
| Priority date | — |
| Expiry date | Sep 5, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to novel analogs of certain peptidase substrates in which the nitrogen atom of the scissile amide bond has been replaced with a difluoromethylene moiety and in which the carbonyl moiety of its adjacent amide bond has been replaced with a terminal amine function, said novel analogs having the property of inhibiting renin and which are useful in the treatment of hypertension.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.