Spiropiperidine derivatives
US5114945A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 23, 1989 |
| Grant date | May 19, 1992 |
| Priority date | — |
| Expiry date | Feb 23, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents hydroxy, C.sub.1-6 alkyl, C.sub.1-6 hydroxyalkyl, C.sub.1-6 carboxyalkyl, phenyl, oxo, amino, carboxy, amido, --NR.sub.4 COR.sub.5 (where R.sub.4 and R.sub.5 both represent C.sub.1-6 alkyl), optionally substituted methylidene or, together with the carbon atom to which it is attached, R.sub.1 forms a 5 or 6-membered ring containing one or more heteroatoms; PA0 R.sub.2 and R.sub.3 are the same or different and are C.sub.1-6 alkyl or C.sub.3-6 alkenyl; or --NR.sub.2 R.sub.3 forms a 5-membered (optionally containing an oxygen atom adjacent to the nitrogen) or a 6-membered ring, which ring optionally contains one unit of unsaturation and which is unsubstituted or substituted by hydroxy, oxo, optionally substituted methylidene, --COR.sub.6 (where R.sub.6 represents C.sub.1-6 alkyl, OR, or --NHR, and R represents hydrogen, C.sub.1-6 alkyl, aryl, ar(C.sub.1-6)alkyl) or .dbd.NOR.sub.8 (where R.sub.8 represents C.sub.1-6 alkyl); PA0 X represents a direct bond, --CH.sub.2 -- or --CH.sub.2 0--; PA0 Ar represents a substituted phenyl moiety; and physiologically acceptable salts thereof. The compounds are indicated as use…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.