Method of inhibiting lung tumors, arylalkyl isothiocyanates, and method of synthesizing same
US5114969A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 31, 1990 |
| Grant date | May 19, 1992 |
| Priority date | — |
| Expiry date | May 31, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of inhibiting lung tumor multiplicity and/or incidence by treating mammals with relatively long chain arylalkyl isothiocyanates, especially effective with respect to tumors induced by exposure to tobacco-specific nitrosamine. Among the isothiocyanates are 4-phenylbutyl isothiocyanate, phenylpentyl isothiocyanate and phenylhexyl isothiocyanate, which are synthesized by adding hydrochloride of phenylbutylamine, phenylpentylamine, or phenylhexylamine in water to thiophosgene in an inert organic solvent. For comparison testing, oxo-pyridyl butyl isothiocyanate is synthesized by dissolving myosmine in HCl to obtain a hydrochloride salt, suspending the salt in dry chloroform, adding thiophosgene, and adding chloroform containing triethylamine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.