Artificial pancreatic perfusion device with temperature sensitive matrix
US5116494A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 25, 1991 |
| Grant date | May 26, 1992 |
| Priority date | — |
| Expiry date | Mar 25, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M1/1678
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A device which serves as an artificial pancreas comprises a hollow fiber which is surrounded by islets of Langerhans enclosed in a housing. The islets are suspended in a temperature sensitive matrix which is sufficiently viscous to support islets at a temperature below about 45.degree. C. and sufficiently fluid to enable removal of islet suspension at a temperature above about 45.degree. C. A warm (e.g., 48.degree. to 50.degree. C.) solution may be flushed through the device to change the physical state of the temperature sensitive matrix from a semi-solid state to a liquified semi-gel state. The temperature sensitive supporting material also enables long term maintenance of islet cells in in vitro culture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.