Rhodanine derivatives and pharmaceutical compositions

US5116855A · kind A · utility

Assignee

• NISSHIN FLOUR MILLING INC. · JP

Inventors

• Hitoshi Inoue · Joetsu, JP
• Hiroki Kato · Saitama, JP
• Noriyoshi Sueda · Saitama, JP
• Yoshiyuki Tahara · Saitama, JP
• Nobuhiro Kinoshita · Saitama, JP

Key dates

• Filing date: May 11, 1990
• Grant date: May 26, 1992
• Expiry date: May 11, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a rhodanine derivative of formula (I). A rhodanine derivative of formula (I) ##STR1## wherein R.sup.1 is hdyrogen, C.sub.1 -C.sub.8 alkyl, carboxyl(C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxycarbonyl(C.sub.1 -C.sub.4)alkyl; PA0 R.sup.2 is --CH.sub.2 --CH.sub.2 --R.sup.3, CH.dbd.CH.sub.m R.sup.3 (m is 0 or 1), ##STR2## (R is C.sub.1 -C.sub.3 alkyl) or --CH.sub.2n CONHR.sup.4 (n is 0 or 1-4); R.sup.3 is a thienyl or furyl group which may be substituted by C.sub.1 -C.sub.3 alkyl or halogen; a pyrrolyl group which may be substituted by carboxy(C.sub.1 -C.sub.3)alkyl on the nitrogen atom; or a phenyl group which may be substituted by one or more substituents selected from the group consisting of C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, hydroxyl, halogen, trifluoromethyl, carboxyl, (C.sub.1 -C.sub.3)alkoxycarbonyl, cyano, carboxy(C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.6)alkoxycarbonyl(C.sub.1 -C.sub.3)alkoxy, benzyloxycarbonyl(C.sub.1 -C.sub.3)alkoxy, piperidinylcarbonyl(C.sub.1 -C.sub.3)alkoxy, 2H-tetrazolyl, 2H-tetrazolyl-(C.sub.1 -C.sub.4)alkoxy, carboxy(C.sub.2 -C.sub.4)alkenyl, (C.sub.1 -C.sub.3)alkoxycarbonyl(C.sub.2 -C.sub.4)alkenyl, carboxy(C.sub.1 -…