HMG-CoA reductase inhibitors

US5116870A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Robert L. Smith · Lansdale, US
• Wasyl Halczenko · Lansdale, US
• George D. Hartman · Lansdale, US
• Gerald E. Stokker · Gwynedd Valley, US
• Edward S. Inamine · Rahway, US
• Otto D. Hensens · Red Bank, US
• David Renwick Houck · Cary, US
• Ta J. Lee · Lansdale, US

Key dates

• Filing date: Jun 6, 1990
• Grant date: May 26, 1992
• Expiry date: Jun 6, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/365
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formula (II): ##STR1##