Synthetic, immunologically active peptides useful for the preparation of antimalarial vaccines
US5116946A · kind A · utility
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Key dates
| Filing date | May 30, 1989 |
| Grant date | May 26, 1992 |
| Priority date | — |
| Expiry date | May 30, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Synthetic peptides constituted by at least two repeating, consecutive units of asparaginyl-proline (Asn-Pro).sub.n sequence, are described. The peptides are powerful immunogens, capable of inducing in laboratory animals the formation of a high concentration of antibodies capable of reacting both with the (Asn-Pro).sub.n peptides, and with the immunodominant epitope of the circumsporozoite protein of Plasmodium falciparum. The peptides, which can be obtained in a pure form by chemical synthesis, are particularly useful for preparing antimalarial vaccines and diagnostic kits for the determination of malaria in man.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.