Macrolide compounds

US5116968A · kind A · utility

Assignee

• American Cyanamid Company · US

Inventors

• Gordon C. Lawrence · Calumet City, US
• Michael John Dawson · Stevenage, GB
• David Noble · Stoke Mandeville, GB
• Michael V. J. Ramsay · Harrow, GB
• Richard Bell · Northolt, GB
• Derek R. Sutherland · Chalfont St Giles, GB
• Edward P. Tiley · Harrow, GB

Key dates

• Filing date: Dec 20, 1990
• Grant date: May 26, 1992
• Expiry date: Dec 20, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P33/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula (1) ##STR1## wherein R represents a sugar residue or an acylated derivative thereof; PA1 R.sup.1 represents a methyl, ethyl or isopropyl group; PA1 Y.sup.1 is --CH.sub.2, Y.sup.2 is --CH-- and X represents ##STR2## [wherein R.sup.2 represents a hydrogen atom or a group OR.sup.6 (where OR.sup.6 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.0, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.7 (where R.sup.7 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group) and the group >C.dbd.NOR.sup.7 is in the E configuration] or --Y.sup.1 --X--Y.sup.2 -- represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--; and PA1 R.sup.4 represents a group OR.sup.6 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which the are attached represent >C.dbd.0 or >C.dbd.NOR.sup.8 (where R.sup.8 is as defined above for R.sup.7), and salts thereof. The compounds may be used to control nematode, acarine, insect or other pests.