N-hydroxy, N-methyl propanamides
US5117054A · kind A · utility
4Cited by
1References
1Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 26, 1991 |
| Grant date | May 26, 1992 |
| Priority date | — |
| Expiry date | Sep 26, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/58
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides a process for preparing 1,5-diaryl pyrazole anti-inflammatory agents. A 6-aryl-4,6-dioxohexanoic acid is treated with acetic anhydride or acetyl chloride to produce an enol lactone, which is added to methylhydroxylamine to generate the dione hydroxamic acid. This dione hydroxamic acid is then treated with 4-methoxyphenylhydrazine hydrochloride to yield the 1,5-diaryl pyrazole. Novel intermediate compounds in the synthetic pathway are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.