Variants of bovine pancreatic trypsin inhibitor and pharmaceutical use thereof

US5118668A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ernst-August Auerswald · Munich, DE
• Wolfgang Bruns · Wuppertal, DE
• Dietrich Horlein · Wuppertal, DE
• Gerd Reinhardt · Kelkheim, DE
• Eugen Schnabel · Wuppertal, DE
• Werner Schroder · Wuppertal, DE

Key dates

• Filing date: Jul 20, 1988
• Grant date: Jun 2, 1992
• Expiry date: Jul 20, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides having essentially the sequence of bovine pancreatic trypsin inhibitor (aprotinin) wherein one or more of the amino acids at positions 15, 16, 17, 18, 34, 39 and 52 are replaced by any naturally occurring amino acid produced by recombinant DNA technology, process, expression vector and recominant host therefor and pharmaceutical use thereof. Such peptides being useful as therapeutic agents in diseases connected with the presence of excessive amounts of proteinases.