Combating endoparasites with 3-hydroxybenzothiophenes

US5118680A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Nikolaus Muller · Monheim, DE
• Werner Hallenbach · Nordhorn, DE
• Achim Harder · Leverkusen, DE
• Werner Lindner · Eppstein, DE

Key dates

• Filing date: Jun 20, 1991
• Grant date: Jun 2, 1992
• Expiry date: Jun 20, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/70
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of combating endoparasites in humans and animals which comprises administering to such humans and animals an endoparasiticidally effective amount of a 3-hydroxybenzothiophene of the formula ##STR1## in which X represents .dbd.CH-- or .dbd.N--, PA1 Y represents .dbd.O or .dbd.NH, PA1 R.sup.1 represents one or more identical or different radicals from the group consisting of hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy and arylthio, which, in turn, may again be substituted, PA1 R.sup.2 represents optionally substituted alkoxy, cycloalkoxy or the radical --NR.sup.3 R.sup.4, PA1 R.sup.3 represents hydrogen or alkyl, PA1 R.sup.4 represents an alkyl or carbocyclic or heterocyclic armoatic radical or the radical --COOR.sup.5, PA1 R.sup.3 and R.sup.4, together with the adjacent nitrogen atom, represent a 5- or 6-membered heterocycle which may contain O or N as further heteroatoms and is optionally substituted by C.sub.1 -C.sub.…