p-Hydroxy phenone derivatives and the use thereof

US5118682A · kind A · utility

Assignee

• BASF SE

Inventors

• Wilfried Lubisch · Mannheim, DE
• Manfred Raschack · Weisenheim am Sand, DE
• Gerda von Philipsborn · Weinheim, DE

Key dates

• Filing date: Jul 12, 1989
• Grant date: Jun 2, 1992
• Expiry date: Jul 12, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C217/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

p-Hydroxy phenone derivatives of the general formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are identical or different and are methyl, chlorine, bromine and hydrogen, but R.sup.1, R.sup.2 and R.sup.3 are not all H, PA0 R.sup.4 and R.sup.5 are identical or different and are H, C.sub.1 -C.sub.4 -alkyl, or OR.sup.6, but R.sup.4 and R.sup.5 are not both H, PA0 X is a --CH.dbd.CH--, --CH.sub.2 CH.sub.2 or --CH.sub.2 -- bridge, PA0 Y is a straight-chain or branched, saturated or unsaturated C.sub.1 -C.sub.4 bridge, and PA0 Z is NR.sup.6 R.sup.7, where R.sup.6 and R.sup.7 are, independently of one another, hydrogen or C.sub.1-4 -alkyl, or Z is a 5- or 6-membered ring with a nitrogen atom in the 1 position and, where appropriate, additionally a second N atom or an O or S atom, the second N atom being substituted by R.sup.7, as well as the physiologically tolerated salts thereof, are used to prepare drugs antiarrhythmic of Vaughan-Williams class III.