Substituted tetrahydropyridines as central nervous system agents

US5118691A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Juan C. Jaen · Plymouth, US
• David G. Nickell · Ann Arbor, US
• Donna M. Reynolds · Plymouth, US
• Sarah J. Smith · Ann Arbor, US
• Lawrence D. Wise · Ann Arbor, US
• David Juergen Wustrow · Ann Arbor, US

Key dates

• Filing date: Jun 17, 1991
• Grant date: Jun 2, 1992
• Expiry date: Jun 17, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.