Efficient large-scale purification of immunoglobulins and derivatives
US5118796A · kind A · utility
78Cited by
3References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 9, 1987 |
| Grant date | Jun 2, 1992 |
| Priority date | — |
| Expiry date | Dec 9, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/864
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Improved methods for direct purification of product immunoglobulins or their derivatives from large volumes of mammalian cell culture medium include directly subjecting the cell culture medium to cation exchange treatment, so as to adsorb the product but not the contaminants. The eluted product is then recycled, or is applied to anion exchange, for further purification, and optionally subjected to additional steps. The product may be obtained in a form suitable for clinical applications, if desired.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.