Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities
US5118811A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Dec 12, 1990 |
| Grant date | Jun 2, 1992 |
| Priority date | — |
| Expiry date | Dec 12, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Amino acid derivatives of the formula ##STR1## wherein: Q is W--(CH.sub.2).sub.m --(A).sub.n --CO--B-- wherein PA2 A is oxygen atom or --NH--; PA2 B is ##STR2## or --(CH.sub.2).sub.l -- wherein X is sulfur atom or --CH.sub.2 --, and l is an integer from 1 to 3; PA2 W is ##STR3## wherein Hal is halogen atom; n is an integer of 0 or 1; and PA2 m is an integer from 0 to 3; PA1 Y is sulfur atom or --CH.sub.2 --; and PA1 R is hydrogen atom, formyl group, C.sub.1-5 alkoxycarbonyl group, --C.tbd.N or ##STR4## wherein R.sup.1 is hydrogen atom, and PA2 R.sup.2 is hydroxyl group, C.sub.1-5 alkylcarboxy group, phenylcarboxy group, C.sub.1-5 alkoxy group or phenyl C.sub.1-5 alkoxy group; PA1 with the proviso that when R is hydrogen atom, formyl group or C.sub.1-5 alkoxycarbonyl group, W is ##STR5## The compounds mentioned above specifically inhibit prolyl endopeptidase activity and are useful as agents for the treatment and prevention of dementia and amnesia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.