Processes for the synthesis of 3-disubstituted aminoacroleins
US5118853A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 26, 1991 |
| Grant date | Jun 2, 1992 |
| Priority date | — |
| Expiry date | Feb 26, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for the synthesis of compounds of the formula ##STR1## comprising the steps of (i) reacting a compound of the formula ##STR2## with oxalyl chloride or oxalyl bromide to form the corresponding compound of the formula ##STR3## (ii) reacting said compound of the formula ##STR4## with a compound of the formula ##STR5## to form the corresponding compound of the formula ##STR6## (iii) hydrolyzing said compound of the formula ##STR7## to obtain the corresponding compound of the formula ##STR8## the use of the compounds of the formula ##STR9## for the synthesis of the compounds of the formula ##STR10## and the use of the intermediates of Formula VII for the direct synthesis of the compounds of Formula II, wherein PA1 R.sub.1 is C.sub.1-3 alkyl, phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C.sub.1-3 alkyl, C.sub.1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), PA1 R.sub.1b is phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C.sub.1-3 alkyl, C.sub.1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), PA1 R.sub.2 is C.sub.1-3 alkyl, one of R.sub.3 and R.sub.4 is ##STR11…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.