Streptenols from streptomycetes, and the preparation and use thereof

US5118882A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Axel Zeeck · Göttingen, DE
• Susanne Grabley · Königstein, DE
• Joachim Wink · Rödermark, DE
• Peter Hammann · Kelkheim, DE
• Carlo Giani · Frankfurt am Main, DE
• Pia Kricke-Helling · Bovenden, DE

Key dates

• Filing date: Feb 22, 1990
• Grant date: Jun 2, 1992
• Expiry date: Feb 22, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P7/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel streptenols with pharmacological activity, in particular with HMG-CoA-reductase inhibiting activity, can be isolated from the nutrient broth of streptomycetes. These compounds can also be used as synthesis unit for the production of mevilonin analogues.