Substituted 3-aminosyndone imines, a process for their preparation and their use

US5120732A · kind A · utility

Assignee

• Cassella Aktiengesellschaft · DE

Inventors

• Karl Schonafinger · Alzenau, DE
• Rudi Beyerle · Frankfurt, DE
• Helmut Bohn · Schöneck, DE
• Melitta Just · Langen, DE

Key dates

• Filing date: Aug 29, 1990
• Grant date: Jun 9, 1992
• Expiry date: Aug 29, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D271/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted 3-aminosydnone imines of the formula I ##STR1## and their pharmacologically acceptable acid addition salts, in which A denotes, for example, --CH.sub.2 --, PA0 R.sup.1 denotes hydrogen or the radical --COR.sup.5, PA0 R.sup.2, R.sup.3 denote alkyl having 1 to 4 C atoms, PA0 R.sup.5 denotes, for example, an aliphatic radical having 1 to 4 C atoms, and methods for preparing such compounds by cyclization of a compound of the formula II ##STR2## and if desired subsequent acylation. The invention also includes formulations containing effective amounts of such compounds, and methods for administering same to patients for the control and prophylaxis of cardiovascular disorders.