Thiazolidinedione hypoglycemic agents
US5120754A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 3, 1991 |
| Grant date | Jun 9, 1992 |
| Priority date | — |
| Expiry date | Apr 3, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond; A and dB are each independently CH or N, with the proviso that when A or B is N, the other is CH; PA0 X is S, SO, SO.sub.2, CH.sub.2, CHOH or CO; PA0 n is 0 or 1; PA0 Y is CHR.sup.1 or NR.sup.2, with the proviso that when n is 1 and Y is NR.sup.2, X is SO.sub.2 or CO; PA0 Z is CHR.sup.3, CH.sub.2 CH.sub.2, CH.dbd.CH, ##STR2## OCH.sub.2, SCH.sub.2, SOCH.sub.2 or SO.sub.2 CH.sub.2 ; R, R.sup.1, R.sup.2 and R.sup.3 are each independently hydrogen or methyl; and PA0 X.sup.1 and X.sup.2 are each independently hydrogen, methyl, trifluoromethyl, phenyl, benzyl, hydroxy, methoxy, phenoxy, benzyloxy, bromo, chloro or fluoro; a pharmaceutically-acceptable cationic salt thereof; or a pharmaceutically-acceptable acid addition salt thereof when A or B is N.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.