Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone
US5122367A · kind A · utility
90Cited by
6References
11Claims
0Family size
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Key dates
| Filing date | Mar 31, 1989 |
| Grant date | Jun 16, 1992 |
| Priority date | — |
| Expiry date | Mar 31, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A controlled release device for the administration of biologically active growth hormone proteins or peptide fragments, and method of preparation thereof, wherein biologically active growth hormone is stabilized and release rate modulated by incorporation of a stabilizing compound. The controlled release devices are prepared by mixing a stabilizer, such as sucrose, with a biologically active growth hormone, such as bovine somatotropic hormone, in solution, lyophilizing, then incorporating the dried powder into a surface erodible, biocompatible polymeric matrix, such as a poly(anhydride) or poly(orthoester) matrix.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.