Dipeptide collagenase inhibitors
US5124322A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 19, 1989 |
| Grant date | Jun 23, 1992 |
| Priority date | — |
| Expiry date | Jun 19, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compounds of formula (I), salts, solvates and hydrates thereof: ##STR1## in which: R.sub.1 and R.sub.2 are independently hydrogen; alkyl; alkoxy; halogen; or CF.sub.3 ; PA1 R.sub.3 is hydrogen; acyl, such as ##STR2## where Z is optionally substituted aryl; or a group R--S-- where R is an organic residue such that the group R--S-- provides an in vivo-cleavable disulphide bond; PA1 R.sub.4 is C.sub.3-6 alkyl; PA1 R.sub.5 is hydrogen; alkyl; --CH.sub.2 --R.sub.10 where R.sub.10 is optionally substituted phenyl or heteroaryl; or a group ##STR3## where R.sub.11 is hydrogen; alkyl; or --CH.sub.2 --Ph is optionally substituted phenyl; and R.sub.12 is hydrogen or alkyl; and PA1 R.sub.6 is hydrogen; alkyl; or a group ##STR4## where R.sub.13 is hydrogen; or alkyl; and R.sub.14 is hydroxy; alkoxy; or --NR.sub.7a R.sub.8 where each of R.sub.7a and R.sub.8 is hydrogen or alkyl, or R.sub.7a and R.sub.8 together with the nitrogen atom to which they are bonded form a 5-, 6- or 7- membered ring with an optional oxygen, sulphur or optionally substituted nitrogen atom in the ring; or PA1 R.sub.5 and R.sub.6 are joined together as --(CH.sub.2).sub.m -- where m is an integer from 4 to 12; PA1 X i…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.