The RESA and FIRA antigens of plasmodium falciparum

US5126264A · kind A · utility

Assignee

• THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH · AU

Inventors

• David J. Kemp · Melbourne, AU
• Robin Fredric Anders · Melbourne, AU
• Ross L. Coppel · Armadale, AU
• Graham V. Brown · Melbourne, AU
• Robert B. Saint · Melbourne, AU
• Alan E. Cowman · Melbourne, AU
• Albert E. Bianco · Melbourne, AU
• Graham F. Mitchell · Melbourne, AU

Key dates

• Filing date: Jul 16, 1990
• Grant date: Jun 30, 1992
• Expiry date: Jul 16, 2010

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

DNA molecules comprising polynucleotide sequences substantially corresponding to all or a portion of the base sequence coding for an antigen of Plasmodium falciparum selected from the group consisting of the RESA antigen, the FIRA antigen, and other antigens of P. falciparum cross-reactive therewith. Such DNA molecules are capable of being expressed as polypeptide(s). Synthetic peptides or polypeptides displaying the antigenicity of all or a portion of the RESA or FIRA antigens of P. falciparum. Compositions for stimulating immune responses against P. falciparum antigens in a mammal, comprising at least one polypeptide displaying the antigenicity of the RESA or FIRA antigens of P. falciparum.