Pancreatic secretory tryspin inhibitor and variants thereof produced by a recombinant host therefore and pharmaceutical use thereof

US5126322A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• John Collins · Cork, IE
• Helmut Blocker · Braunschweig, DE
• Ronald Frank · Lehre, DE
• Friedhelm Maywald · Braunschweig, DE
• Hans Fritz · Höhenkirchen-Siegertsbrunn, DE
• Wolfgang Bruns · Wuppertal, DE

Key dates

• Filing date: Apr 16, 1991
• Grant date: Jun 30, 1992
• Expiry date: Apr 16, 2011

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/27
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a peptide having essentially the amino acid sequence of pancreatic secretory trypsin inhibitor (PSTI). The present invention also relates to variants of such peptide wherein one or more of the amino acids in the original sequence are replaced by other amino acids. These peptides show an advantageously modified specificity in their inhibotory action. A method of preparation of the peptides and their pharmaceutical use is also described.