Anti-inflammatory 1,8-naphthyridin-2-one derivatives
US5126341A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1991 |
| Grant date | Jun 30, 1992 |
| Priority date | — |
| Expiry date | Apr 12, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are naphthyridine derivatives represented by formula (I) ##STR1## wherein: X represents hydrogen; lower alkyl; aralkyl; substituted or unsubstituted aryl; substituted or unsubstituted aromatic heterocyclic group; --NR.sup.1 R.sup.2 wherein R.sup.1 and R.sup.2 independently represent hydrogen or lower alkyl; ##STR2## wherein W represents N or CH, Z represents a single bond, oxygen or NR.sup.3 (wherein R.sup.3 represents hydrogen, lower alkyl or benzyl) and n1 and n2 represent an integer of 1 to 3; or substituted or unsubstituted thiazolinyl; and PA0 Y is a single bond or alkylene and pharmaceutically acceptable salts thereof. The compounds show potent anti-inflammatory activity and are expected to be useful in treating rheumarthritis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.