Anti-inflammatory picolyselenobenzamides and salts thereof

US5126357A · kind A · utility

Assignee

• A NATTERMANN & CIE GMBH · DE

Inventors

• Michel Evers · La Queue-en-Brie, FR
• Michael Parnham · Bad Soden am Taunus, DE
• Axel Romer · Frechen, DE
• Hartmut Fischer · Hofheim, DE
• Norbert Dereu · Viry-Châtillon, FR

Key dates

• Filing date: Nov 8, 1990
• Grant date: Jun 30, 1992
• Expiry date: Nov 8, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/60
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound or a pharmaceutically acceptable salt thereof, having anti-inflammatory activity, is disclosed according to the Formula (I) ##STR1## wherein R is hydrogen, methyl or ethyl, PA0 R.sub.1 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group or is phenyl, chlorophenyl or fluorophenyl, PA0 R.sub.2 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group, PA0 R.sub.3 and R.sub.4 are identical or different and, taken separately, are hydrogen, fluorine, chlorine, bromine, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, cyano or nitro or, taken together, are methylenedioxy, and n is 0 or 1.