Methods and compositions for the preparation and use of site-directed immunologic reagents
US5126399A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jun 20, 1989 |
| Grant date | Jun 30, 1992 |
| Priority date | — |
| Expiry date | Jun 20, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/32122
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are peptidyl-resin conjugates made up of an immunogenic/antigenic peptide conjugated to a polyamide resin, wherein the peptide incorporates a helper T-cell epitope. The inclusion of a T-cell epitope in this peptide sequence provides particular benefits in the preparation of site-directed reagents intended as immunogens. In exemplary studies, a synthetic peptide predicted from Abelson murine leukemia virus abl oncogene (residues 389-403) was synthesized with a T-cell active epitope of 7 amino acids placed at its N-terminus (T-abl-resin). The T-abl-resin construct was found to greatly stimulate the immune response giving significantly higher specific antibody titers than abl-resin controls.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.