Aldophosphamide glycosides, a process for their preparation and their use as pharmaceutical active compounds

US5126437A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Lutz F. Tietze · Göttingen, DE
• Manfred Neumann · Marl, DE
• Roland Fischer · Bochum, DE

Key dates

• Filing date: Jun 7, 1989
• Grant date: Jun 30, 1992
• Expiry date: Jun 7, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## in which R.sup.1 represents saturated, unsaturated or anhydro desoxypentosyl, desoxyhexosyl or didesoxyhexosyl, where the OH functions of the sugar are optionally protected, and PA1 R.sup.2 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms and PA1 R.sup.3 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms and PA1 X represents halogens and PA1 R.sup.4 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms. Such compounds are useful as highly selective cytostatics in cancer therapy.