Synthesis of purine substituted cyclopentene derivatives

US5126452A · kind A · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• Robert Vince · Windom, US
• Mark L. Peterson · Forestville, CA
• John W. Lackey · Hillsborough, US
• Robert Mook · Chapel Hill, US
• John J. Partridge · Upper Montclair, US

Key dates

• Filing date: Apr 6, 1990
• Grant date: Jun 30, 1992
• Expiry date: Apr 6, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to new process for preparing certain optically active purine substituted cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1R-cis isomer of carbovir, (1R-cis)-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-pur in-6-one, an antiviral agent, and certain intermediates.