Synthetic peptide antagonists of neurokinin A, salts thereof and respective preparation processes

US5128447A · kind A · utility

Assignee

• A. Menarini Industrie Farmaceutiche Riunite S.R.L. · IT

Inventors

• Paolo Rovero · Firenze, IT
• Vittorio Pestellini · Firenze, IT
• Carlo Alberto Maggi · Firenze, IT
• Riccardo Patacchini · Parma, IT
• Paolo Santicioli · Arezzo, IT
• Sandro Giuliani · Bagno a Ripoli, IT
• Alberto Meli · Firenze, IT

Key dates

• Filing date: May 24, 1990
• Grant date: Jul 7, 1992
• Expiry date: May 24, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A synthetic peptide corresponding to the following formula: EQU X--Asp--Y--DTrp--Val--DTrp--Z--K--NH.sub.2 where: PA1 X=H, Arg, DArg, Lys, DLys, Thr, DThr PA1 Y=Tyr, Trp, DTrp, Ser, Met PA1 Z=Trp, DTrp PA1 K=Arg, Phe, DTrp, Tyr, Met and pharmaceutically acceptable salts thereof with organic and inorganic acids as competitive antagonists against neurokinin A (NK-2 receptor).