Recombinant trichosanthin and coding sequence
US5128460A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 4, 1990 |
| Grant date | Jul 7, 1992 |
| Priority date | — |
| Expiry date | Apr 4, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are the entire protein and nucleic acid coding sequences for unprocessed and mature trichosanthin protein from Trichosanthes kirilowii. A recombinant trichosanthin protein produced from the coding sequence, and the trichosanthin protein with amino-terminal and/or carboxy-terminal extensions are also described. Primers derived from the coding sequence are disclosed for use in obtaining the coding sequences of ribosome-inactivating-proteins which have regions of amino acid sequence identical to those of trichosanthin. Further, a multigene family of ribosome-inactivating-protein encoding genes of Trichosanthes kirilowii is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.