Resolution of furopyridine enantiomers and synthetic precursors thereof
US5130252A · kind A · utility
2Cited by
4References
18Claims
0Family size
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Key dates
| Filing date | May 14, 1990 |
| Grant date | Jul 14, 1992 |
| Priority date | — |
| Expiry date | May 14, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/004
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for resolving racemic mixtures of compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof that includes the steps of reacting the OR.sub.3 group of either compound with an esterifying agent in the case where R.sub.3 is H or a lower alkyl group; sujecting the compound to the action of an esterase capable of preferentially hydrolyzing either the (+) or (-) enantiomeric form of the compound; and separating the unhydrolyzed compound from the hydrolyzed compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.